Anatomic and Cellular Niches for Mycobacterium tuberculosis in Latent Tuberculosis Infection

Jonathan Mayito; Irene Andia; Mulugeta Belay; David A Jolliffe; David P Kateete; Stephen T Reece; Adrian R Martineau

doi:10.1093/infdis/jiy579

Anatomic and Cellular Niches for Mycobacterium tuberculosis in Latent Tuberculosis Infection

J Infect Dis. 2019 Feb 15;219(5):685-694. doi: 10.1093/infdis/jiy579.

Authors

Jonathan Mayito^{1

2}, Irene Andia¹, Mulugeta Belay², David A Jolliffe², David P Kateete¹, Stephen T Reece³, Adrian R Martineau²

Affiliations

¹ Department of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda.
² Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom.
³ Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.

Abstract

Latent tuberculosis has been recognized for over a century, but discovery of new niches, where Mycobacterium tuberculosis resides, continues. We evaluated literature on M.tuberculosis locations during latency, highlighting that mesenchymal and hematopoietic stem cells harbor organisms in sensitized asymptomatic individuals.

Keywords: CD34; bone marrow; hematopoietic stem cells; latent tuberculosis; mesencymal stem cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Hematopoietic Stem Cells / microbiology*
Humans
Latent Tuberculosis / microbiology*
Latent Tuberculosis / pathology*
Mesenchymal Stem Cells / microbiology*
Mycobacterium tuberculosis / growth & development
Mycobacterium tuberculosis / isolation & purification*
Phagocytes / microbiology*

Abstract

Publication types

MeSH terms

Grants and funding