Statins: a new approach to combat temozolomide chemoresistance in glioblastoma

Shahla Shojaei; Javad Alizadeh; James Thliveris; Navid Koleini; Elissavet Kardami; Grant M Hatch; Fred Xu; Sabine Hombach-Klonisch; Thomas Klonisch; Saeid Ghavami

doi:10.1136/jim-2018-000874

Statins: a new approach to combat temozolomide chemoresistance in glioblastoma

J Investig Med. 2018 Dec;66(8):1083-1087. doi: 10.1136/jim-2018-000874. Epub 2018 Oct 27.

Authors

Shahla Shojaei^{1

2}, Javad Alizadeh¹, James Thliveris¹, Navid Koleini^{3

4}, Elissavet Kardami^{1

3

4}, Grant M Hatch⁵, Fred Xu⁵, Sabine Hombach-Klonisch¹, Thomas Klonisch¹, Saeid Ghavami^{1

6

7}

Affiliations

¹ Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
² Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
⁴ Institute of Cardiovascular Sciences, St. Boniface Hospital AlbrechtsenResearch Center, Winnipeg, Manitoba, Canada.
⁵ Pharmacology & Therapeutics, Max Rady College of Medicine, Rady Faculty of Helath Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
⁶ Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
⁷ Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.

PMID: 30368483
DOI: 10.1136/jim-2018-000874

Abstract

Patients with glioblastoma multiforme (GBM) have an average life expectancy of approximately 15 months. Recently, statins have emerged as a potential adjuvant cancer therapy due to their ability to inhibit cell proliferation and induce apoptosis in many types of cancer. The exact mechanisms that mediate the inhibitory actions of statins in cancer cells are largely unknown. The purpose of this proceeding paper is to discuss some of the known anticancer effects of statins, while focusing on GBM therapy that includes adjunct therapy of statins with chemotherapeutic agents.

Keywords: brain diseases; cancer; cell death; cholesterol.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Drug Resistance, Neoplasm*
Glioblastoma / drug therapy*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Models, Biological
Temozolomide / therapeutic use*

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Temozolomide