Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy

Dongdong Wang; Ruohong Shi; Jiajia Zhou; Sixiang Shi; Huihui Wu; Pengping Xu; Hui Wang; Guoliang Xia; Todd E Barnhart; Weibo Cai; Zhen Guo; Qianwang Chen

doi:10.1016/j.isci.2018.10.005

Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy

iScience. 2018 Nov 30:9:14-26. doi: 10.1016/j.isci.2018.10.005. Epub 2018 Oct 12.

Authors

Dongdong Wang¹, Ruohong Shi¹, Jiajia Zhou², Sixiang Shi³, Huihui Wu², Pengping Xu¹, Hui Wang⁴, Guoliang Xia¹, Todd E Barnhart³, Weibo Cai⁵, Zhen Guo⁶, Qianwang Chen⁷

Affiliations

¹ Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
² Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
³ Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.
⁴ The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China. Electronic address: hw39@hmfl.ac.cn.
⁵ Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: wcai@uwhealth.org.
⁶ Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China. Electronic address: zhenguo@ustc.edu.cn.
⁷ Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China. Electronic address: cqw@ustc.edu.cn.

Abstract

Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy.

Keywords: Biological Sciences; Catalysis; Chemistry; Drug Delivery System; Inorganic Chemistry.

Grants and funding

P30 CA014520/CA/NCI NIH HHS/United States