TDP-43 mutations increase HNRNP A1-7B through gain of splicing function

Brain. 2018 Dec 1;141(12):e83. doi: 10.1093/brain/awy260.

Affiliations

¹ Department of Neuromuscular Diseases, Institute of Neurology, Queen Square, University College London, UK.
² Mammalian Genetics Unit, MRC Harwell Institute, Oxford, UK.
³ University College London Genetics Institute, Gower Street, London, UK.
⁴ Unidad de Investigación, Hospital Universitario de Canarias, Fundación Canaria de Investigación Sanitaria and Instituto de Tecnologías Biomédicas, La Laguna, Spain.

PMID: 30364928
DOI: 10.1093/brain/awy260

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alternative Splicing
Amyotrophic Lateral Sclerosis*
DNA-Binding Proteins
Heterogeneous Nuclear Ribonucleoprotein A1
Heterogeneous-Nuclear Ribonucleoprotein Group A-B*
Humans
Mutation
RNA Splicing

Substances

DNA-Binding Proteins
Heterogeneous Nuclear Ribonucleoprotein A1
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
TARDBP protein, human

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