A new nano air filter for fine dust filtration with antibacterial and volatile organic compounds (VOCs) adsorption properties was fabricated using a bottom-up, high-speed electrospinning system. To optimize production, polyurethane fibers were electrospun at various voltages on polypropylene nonwoven fabrics, and results show that fiber diameter decreased as voltage increased. Silver nanoparticles (AgNPs) and Activated Carbon (AC) were used as antimicrobials and VOC-reducing agents. FTIR, SEM, and EDS were performed to analyze the resulting filter fabricated by electrospinning. FTIR and EDS results show that the AgNPs and activated carbon added to the PU fibers were successfully integrated into the PP nonwoven fabric.