Naturally-derived biomaterials have been used for decades in multiple regenerative medicine applications. From the simplest cell microcarriers made of collagen or alginate, to highly complex decellularized whole-organ scaffolds, these biomaterials represent a class of substances that is usually first in choice at the time of electing a functional and useful biomaterial. Hence, in this chapter we describe the several naturally-derived biomaterials used in tissue engineering applications and their classification, based on composition. We will also describe some of the present uses of the generated tissues like drug discovery, developmental biology, bioprinting and transplantation.
Keywords: Extracellular matrix-derived biomaterials; Glycosaminoglycans; Naturally-derived materials; Polysaccharide-based biomaterials; Protein-based biomaterials; Regulatory landscape for naturally-derived biomaterials; Solid organ bioengineering; Tissue decellularization; Tissue engineering.