Cytological diagnosis of adrenocortical carcinoma: A report of 2 cases in children

Diagn Cytopathol. 2018 Dec;46(12):1064-1067. doi: 10.1002/dc.24056. Epub 2018 Oct 24.

Abstract

Adrenocortical carcinoma (ACC) is a rare tumour, which sometimes affects pediatric age group. Fine needle aspiration cytology (FNAC) is a rarely performed technique in adrenal cortical tumours. There is sparse literature available describing the cytological findings of ACCs in children. Here we describe the cytological findings of 2 cases of ACCs in children. The first case describes the FNAC findings in a 4 year old girl who presented with a large abdominal mass. The second case narrates the intra-operative imprint cytology findings in a 2-year-old boy who came with precocious puberty. However, diagnosis of adrenocortical tumours based on cytology alone can be difficult and definitive diagnosis should be made after correlating cytological features with the clinical profile, radiology, histopathology, and immunohistochemistry.

Keywords: adrenocortical tumours, FNAC, imprint cytology, pediatric age group.

Publication types

  • Case Reports

MeSH terms

  • Adrenocortical Carcinoma / diagnosis*
  • Adrenocortical Carcinoma / pathology*
  • Biopsy, Fine-Needle / methods
  • Child, Preschool
  • Cytodiagnosis / methods
  • Female
  • Humans
  • Immunohistochemistry / methods
  • Male