Optimization of Antipsychotic and Benzodiazepine Drugs in Patients with Severe Mental Disorders in an Intensive Case Management Program

Community Ment Health J. 2019 Jul;55(5):819-824. doi: 10.1007/s10597-018-0349-2. Epub 2018 Oct 23.

Abstract

The Intensive Case Management (ICM) model is a community-based program for people with severe mental illness that may reduce hospitalization and increase retention in care. The aims of this study were to analyze changes in the antipsychotic and benzodiazepine dosage in 106 patients who participated in an Individualized Service Program based on the ICM model for at least 6 months and to assess the change in the number of patients taking a high or very high dose of an antipsychotic drug and the number receiving antipsychotic polytherapy. Both the average daily dose of antipsychotic and benzodiazepine drugs and the number of patients with high doses of antipsychotic and more than one antipsychotic drug decreased significantly. Implementing the ICM program in patients with severe mental illness could help to decrease adverse drug effects and health care expenditures.

Keywords: Antipsychotics; Assertive Community Treatment; Benzodiazepines; Intensive Case Management; Psychosis; Severe mental illness.

Publication types

  • Systematic Review

MeSH terms

  • Benzodiazepines / administration & dosage*
  • Case Management*
  • Critical Care*
  • Drug Therapy, Combination
  • Female
  • Hallucinations / drug therapy
  • Hospitalization
  • Humans
  • Male
  • Mental Disorders / drug therapy*
  • Severity of Illness Index

Substances

  • Benzodiazepines