A call to arms: Unifying the fight against resistance

Alexis Kaushansky; Lizbeth Hedstrom; Aaron Goldman; Juswinder Singh; Priscilla L Yang; Pradipsinh K Rathod; Michael Cynamon; Dominik Wodarz; Daruka Mahadevan; Andrew Tomaras; Manuel A Navia; Celia A Schiffer

doi:10.1126/scisignal.aav0442

A call to arms: Unifying the fight against resistance

Sci Signal. 2018 Oct 23;11(553):eaav0442. doi: 10.1126/scisignal.aav0442.

Authors

Alexis Kaushansky^{1

2}, Lizbeth Hedstrom³, Aaron Goldman^{4

5}, Juswinder Singh⁶, Priscilla L Yang⁷, Pradipsinh K Rathod⁸, Michael Cynamon⁹, Dominik Wodarz¹⁰, Daruka Mahadevan¹¹, Andrew Tomaras¹², Manuel A Navia¹³, Celia A Schiffer^{14

15}

Affiliations

¹ Department of Global Health, University of Washington, Seattle, WA 98109, USA. alexis.kaushansky@seattlechildrens.org.
² Center for Infectious Disease Research, Seattle, WA 98109, USA.
³ Departments of Biology and Chemistry, Brandeis University, Waltham, MA 02453, USA.
⁴ Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
⁵ Division of Biomedical Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
⁶ Ankaa Therapeutics LLC, Southborough, MA 01772, USA.
⁷ Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
⁸ Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
⁹ Department of Medicine, Veterans Affairs Medical Center, Syracuse, NY 13210, USA.
¹⁰ Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA 92697, USA.
¹¹ Department of Medicine, University of Arizona, Tucson, AZ 85724, USA.
¹² BacterioScan Inc., St. Louis, MO 63108, USA.
¹³ Hub-Bio Strategic Advising, Lexington, MA 02420, USA.
¹⁴ Institute of Drug Resistance, Worcester, MA 01605, USA.
¹⁵ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract

This Editorial discusses the state of research on drug resistance in the fields of cancer, infectious disease, and agriculture. Reaching across the aisle for a more cross-collaborative approach may lead to exciting breakthroughs toward tackling the challenges of drug resistance in each field.

Publication types

Editorial
Research Support, N.I.H., Extramural

MeSH terms

Agriculture
Communicable Diseases / drug therapy
Drug Resistance, Microbial*
Drug Resistance, Neoplasm*
Humans
Interdisciplinary Communication
Mutation
Neoplasms / drug therapy*
Stochastic Processes

Abstract

Publication types

MeSH terms

Grants and funding