Instability of microsatellites linked to targeted genes in CRISPR/Cas9-edited and traditional gene knockout mouse strains

J Genet Genomics. 2018 Oct 20;45(10):553-556. doi: 10.1016/j.jgg.2018.07.010. Epub 2018 Oct 10.

Authors

Xueyun Huo¹, Xiulin Zhang¹, Yihan Liu¹, Yizhu Sun¹, Yu Ren¹, Changlong Li¹, Xiaoyan Du², Zhenwen Chen¹

Affiliations

¹ School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing 100069, China.
² School of Basic Medical Sciences, Capital Medical University, Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing 100069, China. Electronic address: duduyan@ccmu.edu.cn.

PMID: 30352733
DOI: 10.1016/j.jgg.2018.07.010

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
CRISPR-Cas Systems*
Gene Editing
Gene Knockout Techniques / adverse effects*
Gene Knockout Techniques / methods
Genomic Instability
Mice / genetics*
Mice, Knockout
Microsatellite Repeats*