Abstract
Cytochathiazines A-C (1-3), which represent a new type of merocytochalasan, were isolated from coculture of Chaetomium globosum and Aspergillus flavipes. Compounds 1-3 are the first natural products featuring an unprecedented 2 H-1,4-thiazine functionality. Plausible biosynthetic pathways for 1-3 with a chaetoglobosin and a dipeptide as the main constitutional units were proposed. Compound 2 induced apoptosis in leukemia cells through the activation of caspase-3 and the degradation of poly ADP-ribose polymerase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Aspergillus / chemistry*
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Biosynthetic Pathways
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Caspase 3 / metabolism
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Cell Line, Tumor
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Cell Survival / drug effects
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Chaetomium / chemistry*
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Coculture Techniques
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Drug Screening Assays, Antitumor
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Humans
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Leukemia / pathology
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Molecular Structure
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Structure-Activity Relationship
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Thiazines / chemistry*
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Thiazines / pharmacology
Substances
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Antineoplastic Agents
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Thiazines
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CASP3 protein, human
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Caspase 3