When Small Molecules Are Like Real Estate: It's All about Location, Location, Location

Michael DeRan; Bridget K Wagner

doi:10.1016/j.chembiol.2018.10.004

When Small Molecules Are Like Real Estate: It's All about Location, Location, Location

Cell Chem Biol. 2018 Oct 18;25(10):1169-1170. doi: 10.1016/j.chembiol.2018.10.004.

Authors

Michael DeRan¹, Bridget K Wagner²

Affiliations

¹ Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
² Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA. Electronic address: bwagner@broadinstitute.org.

PMID: 30339956
DOI: 10.1016/j.chembiol.2018.10.004

Abstract

In this issue of Cell Chemical Biology, Park et al. (2018) demonstrate that targeting apoptazole, an Hsp70 inhibitor, to mitochondria induces apoptosis by a distinct mechanism of action different from unmodified apoptazole, which accumulates in the lysosome. These results highlight the power of subcellular localization in small-molecule selectivity.

Publication types

Comment

MeSH terms

Apoptosis*
HSP70 Heat-Shock Proteins*
Lysosomes
Mitochondria

Substances

HSP70 Heat-Shock Proteins