Ir(COD)Cl]2/Tris(2,4-di- t-butylphenyl)phosphite-Catalyzed Addition Reactions of Arylboronic Acids with Aldehydes

Yuan-Xi Liao; Jie Dong; Qiao-Sheng Hu

doi:10.1016/j.tetlet.2018.02.071

Ir(COD)Cl]₂/Tris(2,4-di- t-butylphenyl)phosphite-Catalyzed Addition Reactions of Arylboronic Acids with Aldehydes

Tetrahedron Lett. 2018 Apr 18;59(16):1548-1550. doi: 10.1016/j.tetlet.2018.02.071. Epub 2018 Mar 2.

Authors

Yuan-Xi Liao¹, Jie Dong¹, Qiao-Sheng Hu¹

Affiliation

¹ Department of Chemistry, College of Staten Island of the City University of New York, Staten Island, New York, 10314 and the Ph.D. Program in Chemistry, the Graduate Center of the City University of New York, New York, NY 10016, United States.

Abstract

[Ir(COD)Cl]₂/tris(2,4-di-t-butylphenyl)phosphite-catalyzed addition reactions of arylboronic acids with aldehydes were described. The Ir(I) catalyst, generated from [Ir(COD)Cl]₂ and tris(2,4-di-t-butylphenyl)phosphite, was an efficient catalyst system for the addition reactions of a variety of arylboronic acids with aromatic and aliphatic aldehydes. The easy availability of the catalyst and good yields make these reactions potentially useful in organic synthesis.

Keywords: Addition Reactions; Aldehydes; Arylboronic acids; Iridium(I); Phosphite.

Grants and funding

R15 GM094709/GM/NIGMS NIH HHS/United States