Thyroid Nodule DNA Methylation Signatures: An Important Diagnostic Annotation

Clin Cancer Res. 2019 Jan 15;25(2):457-459. doi: 10.1158/1078-0432.CCR-18-2820. Epub 2018 Oct 16.

Abstract

Molecular profiling in thyroid cancer has made significant progress in part due to advances in somatic mutation profiling. Yet, differentiating benign from malignant thyroid nodules remains elusive. A unique set of DNA methylation signatures has the potential of improving thyroid cancer molecular diagnostics based on the DNA methylome.See related article by Yim et al., p. 544.

Publication types

  • Comment

MeSH terms

  • DNA
  • DNA Methylation
  • Humans
  • Thyroid Neoplasms / genetics*
  • Thyroid Nodule*

Substances

  • DNA