Objective: To investigate the combined effects of hepatitis B virus and hepatitis C virus (HBV/HCV) infection on the cause of death in patients with acquired immunodeficiency syndrome (AIDS). Methods: The causes of death of 111 cases of AIDS with HBV/HCV (combined infection group) and 210 AIDS patients (single infection group) admitted to our hospital from 2012 to 2016 data were compared using chi-square test. Results: There was no statistically significant difference in gender composition and age in the combined infection groups (P > 0.05). The main causes of death in the combined infection group were severe pneumonia (44.1%), end-stage liver disease (18.9%), and central nervous system infection (14.4%). The main causes of death in the single infection group were severe pneumonia (47.6%) and central nervous system infection (14.3%) and tumor (13.3%). There was no case of end-stage liver disease. The ratio of end-stage liver disease in the former group was significantly higher than that in the latter group (χ(2) = 42.511, P < 0.001). The main cause of death in 12 HIV/HBV/HCV triple-infected patients was end-stage liver disease, accounting for 41.7%, which was significantly higher than 18.9% of end-stage liver disease in HIV/HBV or HIV/HCV dual infection (99 cases). And the difference was statistically significant (χ(2) = 4.539, P = 0.033); however, the ratio of end-stage liver disease in 50 HIV/HBV co-infected patients and 49 HIV/HCV co-infected patients was 16.0% vs. 16.3%, respectively, and the difference was not statistically significant (χ(2) = 0.002, P = 0.965). In the co-infected group, 36 patients had CD4(+) cell counts >100/μl, the primary cause of death was end-stage liver disease, accounting for 38.2%. 75 patients with CD4(+) ≤ 100/μl died due to end-stage liver disease, accounting for 9.3% and the difference was statistically significant (χ(2) = 13.852, P < 0.05). Conclusion: End-stage liver disease is the main cause of death in patients with AIDS combined with HBV or HCV, especially triplet infection and CD4(+) cell count > 100/μl. An early diagnosis and treatment of HBV or HCV infection should commence as soon as possible.
目的： 探讨合并乙型肝炎病毒/丙型肝炎病毒（HBV/HCV）感染对获得性免疫缺陷综合征(AIDS)患者死亡原因的影响。 方法： 用χ(2)检验分析比较2012年至2016年收治的111例AIDS合并HBV/HCV感染患者（合并感染组）与210例单纯AIDS患者（单一感染组）的死亡原因。 结果： 合并感染组与单一感染组性别构成与年龄比较，均无统计学意义（P值均>0.05）。合并感染组主要死亡原因为：重症肺炎（44.1%）、终末期肝病（18.9%）及中枢神经系统感染（14.4%）；单一感染组主要死亡原因为：重症肺炎（47.6%）、中枢神经系统感染（14.3%）及肿瘤（13.3%），无一例发生终末期肝病；前者终末期肝病比率明显高于后者（χ(2) = 42.511，P < 0.001）。12例HIV/HBV/HCV三重感染患者最主要死因是终末期肝病，占41.7%，明显高于HIV/HBV或HIV/HCV双重感染者（共99例）终末期肝病的18.9%，差异有统计学意义（χ(2) = 4.539，P = 0.033）；然而，50例HIV/HBV合并感染者与49例HIV/HCV合并感染者终末期肝病比率分别为16.0%对比16.3%，差异无统计学意义（χ(2) = 0.002，P = 0.965）。合并感染组中，36例患者CD4(+)细胞计数>100个/μl，首要死因是终末期肝病，占38.2%，而75例CD4 (+) T淋巴细胞≤100个/μl患者死因为终末期肝病的比例为9.3%，χ(2) = 13.852，P < 0.05，差异有统计学意义。 结论： 终末期肝病是AIDS合并HBV或HCV感染者，尤其三重感染及CD4(+)T淋巴细胞计数>100个/μl患者的主要死因，应该尽早对HBV或HCV合并感染进行诊治。.
Keywords: Acquired immunedeficiency syndrome; Cause of death; End-stage liver diseases; Hepatitis B virus; Hepatitis C virus; Human immunodeficiency virus.