Abstract
The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies / genetics
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Antibodies / metabolism*
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Antibody Formation / genetics
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B-Lymphocyte Subsets / immunology*
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B-Lymphocytes / immunology*
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Cell Differentiation
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Dendritic Cells / immunology*
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Germinal Center / immunology*
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Immunoglobulin Class Switching / genetics
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Immunoglobulin M / genetics*
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Immunoglobulin M / metabolism
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Lymphocyte Activation
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Membrane Proteins / metabolism
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Mice
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T-Lymphocytes / immunology*
Substances
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Antibodies
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Immunoglobulin M
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Membrane Proteins