Evaluating the IgMi mouse as a novel tool to study B-cell biology

Eur J Immunol. 2018 Dec;48(12):2068-2071. doi: 10.1002/eji.201847735. Epub 2018 Oct 26.

Abstract

The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / genetics
  • Antibodies / metabolism*
  • Antibody Formation / genetics
  • B-Lymphocyte Subsets / immunology*
  • B-Lymphocytes / immunology*
  • Cell Differentiation
  • Dendritic Cells / immunology*
  • Germinal Center / immunology*
  • Immunoglobulin Class Switching / genetics
  • Immunoglobulin M / genetics*
  • Immunoglobulin M / metabolism
  • Lymphocyte Activation
  • Membrane Proteins / metabolism
  • Mice
  • T-Lymphocytes / immunology*

Substances

  • Antibodies
  • Immunoglobulin M
  • Membrane Proteins