Harmful and protective roles of group V phospholipase A2: Current perspectives and future directions

Sachin K Samuchiwal; Barbara Balestrieri

doi:10.1016/j.bbalip.2018.10.001

Harmful and protective roles of group V phospholipase A₂: Current perspectives and future directions

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):819-826. doi: 10.1016/j.bbalip.2018.10.001. Epub 2018 Oct 8.

Authors

Sachin K Samuchiwal¹, Barbara Balestrieri²

Affiliations

¹ Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
² Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: bbalestrieri@bwh.harvard.edu.

Abstract

Group V Phospholipase A₂ (Pla2g5) is a member of the PLA₂ family of lipid-generating enzymes. It is expressed in immune and non-immune cell types and is inducible during several pathologic conditions serving context-specific functions. In this review, we recapitulate the protective and detrimental functions of Pla2g5 investigated through preclinical and translational approaches. This article is part of a Special Issue entitled Novel functions of phospholipase A₂ Guest Editors: Makoto Murakami and Gerard Lambeau.

Keywords: Asthma; Eicosanoids; Free fatty acids; IL-33; Macrophages; linoleic acid.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Humans
Immunity / immunology
Phospholipases A2 / immunology
Phospholipases A2 / metabolism*

Substances

Phospholipases A2

Abstract

Publication types

MeSH terms

Substances

Grants and funding