Adjunctive protein synthesis inhibitor antibiotics for toxin suppression in Staphylococcus aureus infections: a systematic appraisal

A J Campbell; R Dotel; C C Blyth; J S Davis; S Y C Tong; A C Bowen

doi:10.1093/jac/dky387

Adjunctive protein synthesis inhibitor antibiotics for toxin suppression in Staphylococcus aureus infections: a systematic appraisal

J Antimicrob Chemother. 2019 Jan 1;74(1):1-5. doi: 10.1093/jac/dky387.

Authors

A J Campbell^{1

2

3}, R Dotel⁴, C C Blyth^{1

2

3}, J S Davis^{5

6}, S Y C Tong^{5

7}, A C Bowen^{1

2

3

5}

Affiliations

¹ Perth Children's Hospital, 15 Hospital Avenue, Perth, Western Australia, Australia.
² Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
³ School of Medicine, Division of Paediatrics, University of Western Australia, Perth, Western Australia, Australia.
⁴ Centre for Infectious Diseases and Microbiology, Westmead Hospital, University of Sydney, and Department of Infectious Diseases, Blacktown Hospital, Sydney, New South Wales, Australia.
⁵ Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.
⁶ Department of Infectious Diseases, John Hunter Hospital, Newcastle, New South Wales, Australia.
⁷ Victorian Infectious Disease Service, The Royal Melbourne Hospital, and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia.

PMID: 30307507
DOI: 10.1093/jac/dky387

Abstract

Protein synthesis inhibitor antibiotics inhibit synthesis of new proteins, including exotoxins and other important virulence determinants in Staphylococcus aureus. A summary of the literature regarding the use of adjunctive protein synthesis inhibitors for toxin suppression in the setting of S. aureus infections is presented.

Publication types

Systematic Review

MeSH terms

Animals
Anti-Bacterial Agents / administration & dosage*
Anti-Bacterial Agents / pharmacology
Bacterial Toxins / antagonists & inhibitors
Bacterial Toxins / biosynthesis*
Humans
Protein Synthesis Inhibitors / administration & dosage*
Protein Synthesis Inhibitors / pharmacology
Staphylococcal Infections / drug therapy*
Staphylococcus aureus / drug effects*

Substances

Anti-Bacterial Agents
Bacterial Toxins
Protein Synthesis Inhibitors