Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Elahe Hadavi; Jeroen Leijten; Jenny Brinkmann; Pascal Jonkheijm; Marcel Karperien; Aart van Apeldoorn

doi:10.1089/ten.TEC.2018.0151

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Tissue Eng Part C Methods. 2018 Nov;24(11):628-636. doi: 10.1089/ten.TEC.2018.0151. Epub 2018 Nov 7.

Authors

Elahe Hadavi¹, Jeroen Leijten¹, Jenny Brinkmann², Pascal Jonkheijm², Marcel Karperien¹, Aart van Apeldoorn^{1

3}

Affiliations

¹ 1 Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente , Enschede, The Netherlands .
² 2 MESA+ Institute for Nanotechnology, Molecular Nanofabrication Group, University of Twente , Enschede, The Netherlands .
³ 3 Complex Tissue Regeneration Department, MERLN Institute for Technology Inspired Regenerative Medicine, Maastricht University , Maastricht, The Netherlands .

PMID: 30306836
DOI: 10.1089/ten.TEC.2018.0151

Abstract

This research deals with finding a proper bioengineering strategy for the creation of improved β-cell replacement therapy in type 1 diabetes. It specifically deals with the microenvironment of β-cells and its relationship to their endocrine function.

Keywords: insulin secretion; islet transplantation; type 1 diabetes; β-cell replacement therapies; β-cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Collagen Type IV / chemistry
Collagen Type IV / metabolism*
Fibronectins / chemistry
Fibronectins / metabolism*
Insulin / metabolism*
Insulin Secretion*
Insulinoma / metabolism*
Insulinoma / pathology
Pancreatic Neoplasms / metabolism*
Pancreatic Neoplasms / pathology
Printing, Three-Dimensional
Rats
Tumor Cells, Cultured

Substances

Collagen Type IV
Fibronectins
Insulin