Targeting neuro-immune communication in neurodegeneration: Challenges and opportunities

Aleksandra Deczkowska; Michal Schwartz

doi:10.1084/jem.20181737

Targeting neuro-immune communication in neurodegeneration: Challenges and opportunities

J Exp Med. 2018 Nov 5;215(11):2702-2704. doi: 10.1084/jem.20181737. Epub 2018 Oct 9.

Authors

Aleksandra Deczkowska¹, Michal Schwartz²

Affiliations

¹ Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
² Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel michal.schwartz@weizmann.ac.il.

Abstract

Immune cells patrol the brain and can support its function, but can we modulate brain-immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a well-controlled manner could be developed as a universal therapeutic approach to treat neurodegeneration.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / immunology*
Brain / pathology
Humans
Inflammation / immunology
Inflammation / pathology
Inflammation / therapy
Neurodegenerative Diseases / immunology*
Neurodegenerative Diseases / pathology
Neurodegenerative Diseases / therapy*