Current controversies and developments on the role of lymphadenectomy for penile cancer

Mounsif Azizi; Juan Chipollini; Charles C Peyton; Salim K Cheriyan; Philippe E Spiess

doi:10.1016/j.urolonc.2018.08.017

Current controversies and developments on the role of lymphadenectomy for penile cancer

Urol Oncol. 2019 Mar;37(3):201-208. doi: 10.1016/j.urolonc.2018.08.017. Epub 2018 Oct 6.

Authors

Mounsif Azizi¹, Juan Chipollini², Charles C Peyton², Salim K Cheriyan², Philippe E Spiess²

Affiliations

¹ Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL. Electronic address: mounsif.azizi@moffitt.org.
² Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.

PMID: 30301700
DOI: 10.1016/j.urolonc.2018.08.017

Abstract

Penile squamous cell carcinoma is a rare cancer in men. The main prognosticators of survival for penile cancer patients remain the presence and the extent of lymph node metastasis. While radical inguinal lymphadenectomy has been the cornerstone of regional lymph node management for many years, it is still associated with significant morbidity and psychological distress. Recent developments in penile squamous cell carcinoma management have been met with some controversy in the urologic oncology community. Herein, we review the current controversies and developments on the role of inguinal lymphadenectomy for penile cancer.

Keywords: Lymph node metastasis; Lymphadenectomy; Minimally invasive surgery; Penile squamous cell carcinoma; Systemic therapy.

Publication types

Review

MeSH terms

Biomarkers, Tumor / analysis
Carcinoma, Squamous Cell / diagnosis
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / therapy*
Chemoradiotherapy / methods
Humans
Inguinal Canal
Lymph Node Excision / adverse effects
Lymph Node Excision / methods*
Lymphatic Metastasis / diagnosis*
Lymphatic Metastasis / pathology
Lymphatic Metastasis / therapy
Male
Minimally Invasive Surgical Procedures / adverse effects
Minimally Invasive Surgical Procedures / methods
Neoadjuvant Therapy / methods
Neoplasm Staging
Penile Neoplasms / diagnosis
Penile Neoplasms / pathology
Penile Neoplasms / therapy*
Postoperative Complications / epidemiology
Postoperative Complications / etiology
Postoperative Complications / prevention & control*
Prognosis
Salvage Therapy / adverse effects
Salvage Therapy / methods
Sentinel Lymph Node / diagnostic imaging
Sentinel Lymph Node / pathology
Sentinel Lymph Node / surgery
Sentinel Lymph Node Biopsy

Substances

Biomarkers, Tumor