Abstract
SAGA and TFIID are related transcription complexes, which were proposed to alternatively deliver TBP at different promoter classes. Recent genome-wide studies in yeast revealed that both complexes are required for the transcription of a vast majority of genes by RNA polymerase II raising new questions about the role of coactivators.
Keywords:
RNA polymerase II; SAGA complex; TFIID complex; coactivator; nascent RNA.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Models, Genetic*
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RNA Polymerase II / chemistry
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RNA Polymerase II / metabolism
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RNA Polymerase II / physiology*
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RNA, Messenger / chemistry
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RNA, Messenger / metabolism
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Trans-Activators / chemistry
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Trans-Activators / metabolism
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Trans-Activators / physiology
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Transcription Factor TFIID / chemistry
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Transcription Factor TFIID / metabolism
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Transcription Factor TFIID / physiology
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Transcription, Genetic / physiology*
Substances
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RNA, Messenger
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Trans-Activators
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Transcription Factor TFIID
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RNA Polymerase II