Bilateral anterior uveitis after immunotherapy for malignant melanoma

Taiwan J Ophthalmol. 2018 Jul-Sep;8(3):173-175. doi: 10.4103/tjo.tjo_88_17.

Abstract

Immune checkpoint blockade therapy is relatively a new treatment for cancer which has shown promising results. However, immune-related side effects including uveitis have occasionally been reported during this therapy. Herein, we report the case of a 65-year-old male who suffered bilateral anterior uveitis after immune checkpoint blockade therapy with pembrolizumab and ipilimumab for malignant melanoma. His symptoms and signs improved after topical treatment with corticosteroids. Clinicians should be aware that uveitis can be an immune-related adverse event of immunotherapy.

Keywords: Immune checkpoint blockade; ipilimumab; pembrolizumab; uveitis.

Publication types

  • Case Reports