Analgesic effect of preoperative dezocine-based local anesthesia in patients undergoing inguinal hernia repair

J Int Med Res. 2018 Dec;46(12):4945-4951. doi: 10.1177/0300060518781708. Epub 2018 Oct 8.

Abstract

Objective: This study was performed to investigate the analgesic effects of intramuscular injection of dezocine-based local anesthesia in patients undergoing inguinal hernia repair.

Methods: A total of 120 patients underwent local herniorrhaphy from July 2015 to December 2016 and were randomly divided into 2 groups: the dezocine group, in which a preoperative intramuscular injection of dezocine was administered, and the control group, in which no dezocine injection was administered. The patients' pain and comfort levels were evaluated at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours postoperatively.

Results: The visual analog scale scores at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours were significantly lower in the dezocine than control group. In the Bruggemann comfort scale evaluation, patients who received dezocine injections showed significantly greater comfort than those in the control group at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours. No adverse reactions occurred in the dezocine group.

Conclusions: Dezocine-based local anesthesia can attenuate postoperative pain and increase the comfort level during and after herniorrhaphy.

Keywords: Bruggemann comfort scale; Dezocine; herniorrhaphy; inguinal hernia; local anesthesia; preemptive analgesia; visual analog scale.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analgesia / methods*
  • Analgesics, Opioid / administration & dosage*
  • Bridged Bicyclo Compounds, Heterocyclic / administration & dosage*
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Hernia, Inguinal / pathology
  • Hernia, Inguinal / surgery*
  • Herniorrhaphy / adverse effects*
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Pain, Postoperative / drug therapy*
  • Pain, Postoperative / etiology
  • Prognosis
  • Tetrahydronaphthalenes / administration & dosage*
  • Young Adult

Substances

  • Analgesics, Opioid
  • Bridged Bicyclo Compounds, Heterocyclic
  • Tetrahydronaphthalenes
  • dezocine