Macrophages in radiation injury: a new therapeutic target

Lydia Meziani; Eric Deutsch; Michele Mondini

doi:10.1080/2162402X.2018.1494488

Macrophages in radiation injury: a new therapeutic target

Oncoimmunology. 2018 Jul 23;7(10):e1494488. doi: 10.1080/2162402X.2018.1494488. eCollection 2018.

Authors

Lydia Meziani^{1

2}, Eric Deutsch^{1

2

3}, Michele Mondini^{1

2}

Affiliations

¹ Gustave Roussy, Université Paris-Saclay, Inserm U1030, Villejuif, France.
² Inserm U1030, Molecular radiotherapy, Labex LERMIT, DHU TORINO, SIRIC SOCRATE.
³ Département de radiothérapie, Gustave Roussy, Villejuif, France.

Abstract

Radiotherapy can induce toxicity in healthy tissues such as radiation-induced fibrosis (RIF), and macrophages are proposed as new profibrogenic cells. In this Point-of-View, we summarize the role of the immune response in ionizing radiation injury, and we focus on macrophages as a new therapeutic target in RIF.

Keywords: Radiation injury; immune system; lung fibrosis; macrophages; radiation toxicity.

Publication types

Research Support, Non-U.S. Gov't

Grants and funding

This work was supported by the Eli Lilly and Company;INCA [2014-1-PL BIO-03];INSERM;SIRIC SOCRATE;