Abstract
A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Growth factors regulate the proliferation of cells dependent on the current demand. We provide a steady state analysis of the model and rough parameter estimates. Furthermore, we extend the model to include mutations that alter the replicative capacity of cells and introduce differentiation blocks. With these mutations the model develops signs of acute myeloid leukemia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Lineage / genetics*
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Hematopoiesis / genetics*
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Leukemia, Myeloid, Acute / genetics
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Leukemia, Myeloid, Acute / pathology*
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Models, Biological*
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Mutation*
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Myeloid Cells / pathology*
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Neoplastic Stem Cells / pathology
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Signal Transduction / genetics*
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Stochastic Processes
Grants and funding
Funding was partly provided by the private Addison Fischer Institute for Research and Ethical Use of Artificial Intelligence through a grant to PSIORI GmbH, Freiburg. FJ and OW were employees of PSIORI at the time the research was conducted. SL is the CEO of PSIORI. There was no additional external funding received for this study. The funders had no additional role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of the authors are articulated in the ‘author contributions’ section.