Self-Assembling Protein Nanoparticles: implications for HIV-1 vaccine development

Nanomedicine (Lond). 2018 Sep;13(17):2121-2125. doi: 10.2217/nnm-2018-0222. Epub 2018 Oct 1.

Authors

Christopher P Karch^{1

2}, Gary R Matyas¹, Peter Burkhard³, Zoltan Beck^{1

2}

Affiliations

¹ US Military HIV Research Program, Laboratory of Adjuvant and Antigen Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA.
² Henry M Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA.
³ Alpha-O Peptides, Lörracherstrasse 50, 4125 Riehen, Switzerland.

PMID: 30270731
DOI: 10.2217/nnm-2018-0222

No abstract available

Keywords: HIV-1; SAPN; antigen density; conformational antibody; nanoparticle; trimeric epitope; vaccine.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

AIDS Vaccines / chemistry
AIDS Vaccines / immunology*
Animals
Computer Simulation
Epitopes
HIV Antigens / immunology
HIV-1 / immunology*
Humans
Nanoparticles / chemistry*
Protein Binding
Protein Conformation
Protein Multimerization
Proteins / chemistry*

Substances

AIDS Vaccines
Epitopes
HIV Antigens
Proteins