Addressing cancer immunotherapy research in Iran: adoptive cell therapy on the horizon

Cytotherapy. 2018 Oct;20(10):1227-1237. doi: 10.1016/j.jcyt.2018.08.002. Epub 2018 Sep 26.

Abstract

Recent advances in immunotherapeutic modalities have profoundly changed the prospect of cancer treatment. These modalities mainly focus on modulating the immune response toward tumor cells by using monoclonal antibodies, cancer vaccines, adoptive cell transfer or combination of these methods. In the last few years, Iranian scientists have conducted several projects in these arenas. Here, we provide an overview of these studies and analyze the quality and trend of publications in each sub-specialty of the field. In addition, the contribution of different universities and scientific institutes is assessed. This study may benefit scientific community and policymakers to plan future cancer immunotherapies in Iran and other countries.

Keywords: adoptive immunotherapy; cancer immunotherapy; cancer vaccine; monoclonal antibody.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adoptive Transfer / methods
  • Antibodies, Monoclonal / therapeutic use
  • Biomedical Research / methods*
  • Cancer Vaccines / immunology
  • Cancer Vaccines / therapeutic use*
  • Cell- and Tissue-Based Therapy / methods*
  • Clinical Trials as Topic / statistics & numerical data
  • Humans
  • Immunotherapy / methods*
  • Immunotherapy, Adoptive / methods
  • Iran
  • Neoplasms / immunology
  • Neoplasms / therapy*

Substances

  • Antibodies, Monoclonal
  • Cancer Vaccines