Abstract
Investigations were performed in 47 children, ageing (13.4 ± 2.4) yrs at average, оperated on for abdominal tumors — 24 (51%), and retroperitoneal — 23 (49%). Complex investigation of the pain behavior reactions, physiological indices and laboratory stresstests have witnessed, that application of the regional anesthesia methods for postoperative anesthesia have had secured effective analgesia after traumatic operative interventions in children. In early postoperative period in children, оperated on for abdominal tumors, hyperalgesia occurrence is possible. Application of regional analgesia scheme have promoted reduction of hyperalgesia and TLR—4 (Tole—like receptors) expression rate in the blood.
MeSH terms
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Adolescent
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Anesthesia, Conduction / methods*
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Anesthesia, General / methods*
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Anesthetics, Local
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Biomarkers / blood
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Bupivacaine
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Child
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Female
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Fentanyl
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Humans
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Hyperalgesia / physiopathology
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Hyperalgesia / prevention & control*
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Male
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Pain Measurement / methods*
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Pain, Postoperative / physiopathology
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Pain, Postoperative / prevention & control*
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Peritoneal Neoplasms / diagnosis
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Peritoneal Neoplasms / pathology
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Peritoneal Neoplasms / surgery
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Postoperative Period
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Retroperitoneal Neoplasms / diagnosis
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Retroperitoneal Neoplasms / pathology
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Retroperitoneal Neoplasms / surgery
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Toll-Like Receptor 4 / blood
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Treatment Outcome
Substances
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Anesthetics, Local
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Biomarkers
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TLR4 protein, human
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Toll-Like Receptor 4
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Fentanyl
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Bupivacaine