Meta-analysis of PET/CT Detect Lymph Nodes Metastases of Cervical Cancer

Jianjiang Ruan; Yueqiao Zhang; Hong Ren

doi:10.1515/med-2018-0065

Meta-analysis of PET/CT Detect Lymph Nodes Metastases of Cervical Cancer

Open Med (Wars). 2018 Sep 22:13:436-442. doi: 10.1515/med-2018-0065. eCollection 2018.

Authors

Jianjiang Ruan¹, Yueqiao Zhang², Hong Ren²

Affiliations

¹ Department of Radiology, Shaoxing Shangyu Women and Children Hospital, Zhejiang 312300, China.
² Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.

Abstract

Objective: The aim of this study was to assess the diagnostic value of PET/CT for metastatic lymph nodes in cervical cancer patients.

Methods: Searching in the databases including PubMed, Embase, Web of Science, Cochrane Library and Google Scholar about non-invasive modalities for detecting lymph nodes metastases during 2000~2017. Following further screening, the extracted effective data were calculated by Meta-Disc 1.4 software, such as sensitivity (SEN), specificity (SPE), positive likelihood (LR+), and negative likelihood ratio (LR-).

Results: we obtained 27 articles. The pooled estimates for sensitivity of PET/CT were 0.72 (95% CI, [0.69, 0.75]); for specificity were 0.96 (95% CI, [0.96, 0.97]). Its weighted AUC was 0.93.

Conclusion: PET/CT remains to be an effective method for diagnosis of metastatic lymph nodes from cervical cancer.

Keywords: Cervical cancer; Lymph nodes metastases; Meta-analysis; PET/CT.