Cdk6: At the interface of Rb and p53

Sofie Nebenfuehr; Florian Bellutti; Veronika Sexl

doi:10.1080/23723556.2018.1511206

Cdk6: At the interface of Rb and p53

Mol Cell Oncol. 2018 Sep 5;5(5):e1511206. doi: 10.1080/23723556.2018.1511206. eCollection 2018.

Authors

Sofie Nebenfuehr¹, Florian Bellutti¹, Veronika Sexl¹

Affiliation

¹ Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria.

Abstract

In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells.

Keywords: CDK6; oncogene induced stress; p53.

Grants and funding

This work was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme grant agreement No 694354.