Dynamic ERK signaling regulation in intestinal tumorigenesis

Yu Muta; Michiyuki Matsuda; Masamichi Imajo

doi:10.1080/23723556.2018.1506684

Dynamic ERK signaling regulation in intestinal tumorigenesis

Mol Cell Oncol. 2018 Sep 11;5(5):e1506684. doi: 10.1080/23723556.2018.1506684. eCollection 2018.

Authors

Yu Muta^{1

2}, Michiyuki Matsuda^{1

3}, Masamichi Imajo³

Affiliations

¹ Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
² Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
³ Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.

Abstract

Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently uncovered ERK activity dynamics in the intestinal epithelium. Notably, we showed that ERK activity dynamics are defined by composite regulation from two distinct upstream receptors, and alteration of their functional balance underlies tumor cell-specific traits. Here, we discuss these findings.

Keywords: EGFR; ERK MAP kinase; ErbB2; in vivo imaging; the intestinal epithelium; tumorigenesis.

Grants and funding

M.I. was supported by the Takeda Science Foundation and Japan Society for the Promotion of Science (JSPS) (Grant-in-Aid for Scientific Research (KAKENHI) on Innovative Areas, “Integrated analysis and regulation of cellular diversity” (18H05100) and for Scientific Research (C) (18K06929)). M.M. was supported by the Nakatani Foundation, CREST JPMJCR1654 and JSPS KAKENHI Grant Numbers 15H02397, 15H05949 “Resonance Bio”, and 16H06280 “ABiS”.