Beneficial role and function of fisetin in skin health via regulation of the CCN2/TGF-β signaling pathway

Myung-Soo Shon; Ryeong-Hyeon Kim; O Jun Kwon; Seong-Soo Roh; Gyo-Nam Kim

doi:10.1007/s10068-016-0110-y

Beneficial role and function of fisetin in skin health via regulation of the CCN2/TGF-β signaling pathway

Food Sci Biotechnol. 2016 Mar 31;25(Suppl 1):133-141. doi: 10.1007/s10068-016-0110-y. eCollection 2016.

Authors

Myung-Soo Shon¹, Ryeong-Hyeon Kim¹, O Jun Kwon², Seong-Soo Roh³, Gyo-Nam Kim¹

Affiliations

¹ 1Department of Food, Nutrition and Biotechnology, Kyungnam University, Changwon, 51767 Korea.
² Daegyeong Institute for Regional Industry Evaluation, Daegyeong Institute for Regional Program Evaluation, Daegu, 38542 Korea.
³ 3Department of Herbology, Daegu Haany University, Daegu, 42158 Korea.

Abstract

Skin is composed of multiple layers, including the epidermis, dermis, and hypodermis. Although several biological activities of fisetin have been reported, beneficial effects and the functions of fisetin in skin remain unclear. B16F10 melanoma cells, human skin fibroblasts, and 3T3-L1 cells were used to examine the beneficial effects of fisetin in skin health. α-MSH- and IBMX-induced melanosis in B16F10 melanoma cells was inhibited by fisetin treatment, which also enhanced mRNA expression levels of skin fibril-related genes via the CCN2/TGF-β signaling pathway. Decreased intracellular lipid accumulation via down-regulation of transcriptional factors through activation of the CCN2/TGF-β signaling pathway was observed. A novel function of fisetin in skin health via down-regulation of melanosis and adipogenesis, and up-regulation of skin fibril-related genes was observed. Evidence for development of nutri-cosmetics for skin health is presented.

Keywords: CCN2; TGF-β; fisetin; melanoma; skin.