Simultaneous voltammetric sensing of acetaminophen, epinephrine and melatonin using a carbon paste electrode modified with zinc ferrite nanoparticles

Mikrochim Acta. 2018 Sep 26;185(10):479. doi: 10.1007/s00604-018-3009-x.

Abstract

A highly selective electrochemical sensor was fabricated based on a modified carbon paste electrode with zinc ferrite nanoparticles (ZnFe2O4 NPs). The nanocomposite has attractive properties such as high surface-to-volume ratio and good electrocatalytic activity towards the drugs acetaminophen (AC), epinephrine (EP), and melatonin (MT), best at working voltages of 0.35, 0.09 and 0.55 V (vs. Ag/AgCl), respectively. The linear ranges (and detection limits) are 6.5-135 (0.4) μmol L-1 for AC, 5-100 (0.7) μmol L-1 for EP, and 6.5-145 (3) μmol L-1 for MT. Graphical abstract A novel electrochemical sensor based on a modified carbon paste electrode with zinc ferrite nanoparticles (ZnFe2O4) for the simultaneous detection of the acetaminophen, epinephrine and melatonin was fabricated.

Keywords: Adrenaline; Drug determination; Electrochemical sensor; Nanocomposite.

MeSH terms

  • Acetaminophen / analysis*
  • Carbon / chemistry*
  • Electrochemistry / instrumentation*
  • Electrodes
  • Epinephrine / analysis*
  • Ferric Compounds / chemistry*
  • Melatonin / analysis*
  • Nanoparticles / chemistry*
  • Ointments
  • Time Factors
  • Zinc Compounds / chemistry*

Substances

  • Ferric Compounds
  • Ointments
  • Zinc Compounds
  • Acetaminophen
  • Carbon
  • Melatonin
  • Epinephrine