Computational analysis of linear energy modulation for laser thermal coagulation

Van Nam Tran; Van Gia Truong; Seok Jeong; Hyun Wook Kang

doi:10.1364/BOE.9.002575

Computational analysis of linear energy modulation for laser thermal coagulation

Biomed Opt Express. 2018 May 9;9(6):2575-2587. doi: 10.1364/BOE.9.002575. eCollection 2018 Jun 1.

Authors

Van Nam Tran¹, Van Gia Truong¹, Seok Jeong², Hyun Wook Kang³

Affiliations

¹ Interdisciplinary Program of Marine-Bio, Electrical & Mechanical Engineering, Pukyong National University, Busan, South Korea.
² Division of Gastroenterology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea.
³ Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, South Korea.

Abstract

Accurate treatment planning and monitoring are critical factors to ensure safe and effective outcomes of laser thermal coagulation (LTC). Computational and experimental models based upon linear energy modulation were deployed to predict temperature distribution and thermal damage within ex vivo porcine liver. 1470-nm Gaussian emission was confirmed by using digital imaging and the customized goniometry. The tissue temperature was maintained in the pre-determined range (65~75 °C) to induce thermally destructive volumes of 0.23 cm³ (simulation) and 0.17 ± 0.05 cm³ (experiment) once the applied power was linearly reduced from 3.5 W to 0.2 W in 50 s ("3.5 W fast slope" laser modulation mode). The proposed model may be a useful tool to predict thermal responses of the tissue during LTC.

Keywords: (060.2280) Fiber design and fabrication; (140.3510) Lasers, fiber; (170.1020) Ablation of tissue; (170.3660) Light propagation in tissues; (170.6935) Tissue characterization.