Anaplastic pleomorphic xanthoastrocytoma with leptomeningeal dissemination responsive to BRAF inhibition and bevacizumab

Pediatr Blood Cancer. 2019 Jan;66(1):e27465. doi: 10.1002/pbc.27465. Epub 2018 Sep 25.

Authors

Alissa A Thomas¹, Suzanne M Tucker², Carl J Nelson³, Joshua P Nickerson⁴, Susan R Durham⁵, Alan C Homans⁶

Affiliations

¹ Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont.
² Department of Pathology, University of California San Diego, San Diego, CA.
³ Department of Radiation Oncology, University of Vermont College of Medicine, Burlington, Vermont.
⁴ Department of Diagnostic Radiology, Oregon Health and Science University, Portland, OR.
⁵ Division of Neurosurgery, Department of Surgery, University of Vermont College of Medicine, Burlington, Vermont.
⁶ Department of Pediatrics, Division of Hematology/Oncology, University of Vermont College of Medicine, Burlington, Vermont.

PMID: 30255633
DOI: 10.1002/pbc.27465

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Astrocytoma / drug therapy*
Astrocytoma / pathology
Bevacizumab / administration & dosage
Brain Neoplasms / drug therapy*
Brain Neoplasms / pathology
Female
Humans
Imidazoles / administration & dosage
Meningeal Carcinomatosis / drug therapy*
Meningeal Carcinomatosis / secondary
Mutation
Oximes / administration & dosage
Prognosis
Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
Proto-Oncogene Proteins B-raf / genetics
Pyridones / administration & dosage
Pyrimidinones / administration & dosage

Substances

Imidazoles
Oximes
Pyridones
Pyrimidinones
Bevacizumab
trametinib
BRAF protein, human
Proto-Oncogene Proteins B-raf
dabrafenib