Tumor-suppressive or tumor-supportive: For p53, that is the question

Muhammad Riaz Khan; Mian Wu; Guangzhi Liu

doi:10.1080/23723556.2017.1408537

Tumor-suppressive or tumor-supportive: For p53, that is the question

Mol Cell Oncol. 2018 Feb 27;5(3):e1408537. doi: 10.1080/23723556.2017.1408537. eCollection 2018.

Authors

Muhammad Riaz Khan¹, Mian Wu^{1

2}, Guangzhi Liu¹

Affiliations

¹ Translational Research Institute, School of Medicine, Henan Provincial People's Hospital, Henan University, Zhengzhou, Henan, China.
² CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui, China.

Abstract

We have recently reported a TP53 (known as p53) regulated long noncoding RNA named TRINGS (Tp53-regulated inhibitor of necrosis under glucose starvation). With the aid of TRINGS, p53 was shown to prevent cancer cells against necroptosis under glucose starvation. Our findings suggest that p53 may act as an oncogenic player in metabolic reprogramming.

Keywords: glucose starvation; lncRNA; necroptosis; p53.

Grants and funding

This work was supported by grants from the National Key R&D Program of China (2016YFC1302302) and National Natural Science Foundation of China (81430065 and 31371388).