Design of a Selective Ring-Closing Enyne Metathesis-Reduction for the Generation of Different Synthetic Scaffolds

Abstract

A tandem process of ring-closing enyne metathesis (RCEYM)-reduction using modern ruthenium catalysts and a hydrogen donor is described. This straightforward methodology is useful for C(sp³) generation under mild reaction conditions. Variables such as solvent, catalyst, hydride source, and temperature were adjusted toward the exclusive formation of different products.