Limited-Stage Hodgkin Lymphoma: Minimizing Toxicity

Cancer J. 2018 Sep/Oct;24(5):223-229. doi: 10.1097/PPO.0000000000000329.

Abstract

Early-stage classic Hodgkin lymphoma has been highly curable using extended-field radiation therapy (RT) alone, combined-modality therapy consisting of chemotherapy and RT, and more recently chemotherapy alone. Radiation therapy either to an extended field (extended-field RT) or to various iterations of an involved field (involved-field RT) is potentially associated with late morbidity and mortality, particularly second primary cancers and cardiovascular complications. Treatment with chemotherapy alone, when possible, can achieve a high cure rate while avoiding these risks. This review describes the evolution of treatment for early-stage classic Hodgkin lymphoma.

Publication types

  • Review

MeSH terms

  • Combined Modality Therapy
  • Hodgkin Disease / pathology*
  • Hodgkin Disease / therapy*
  • Humans
  • Neoplasm Staging