Unidirectional porous β-tricalcium phosphate induces bony fusion in lateral lumbar interbody fusion

J Clin Neurosci. 2019 Jan:59:232-235. doi: 10.1016/j.jocn.2018.09.004. Epub 2018 Sep 20.

Abstract

Lateral lumbar interbody fusion (LLIF) often requires the use of allograft or artificial bone. We used β-tricalcium phosphate artificial bone with a porosity of 57% consisting of a novel unidirectional porous structure (Affinos®) in patients (5 male and 9 female) who underwent LLIF from August 2015 as a substitute for autologous bone. We evaluated 60 graft windows in the cages at 30 intervertebral levels. To evaluate interbody bony fusion, CT multi-planar reconstruction coronal and sagittal images obtained 1 year after surgery were assessed. Intra-cage bony fusion was observed in 39 of 60 graft windows and so total bony fusion rate was 65%. Intra-cage bony fusion was confirmed in 17 of 29 (58.6%) graft windows with autologous bone and 22 of 31 (70.9%) graft windows with Affinos®. There was no significant difference in the rate of bony fusion between autologous bone and Affinos® (p = 0.418). In conclusion, the rate of bony fusion using Affinos® in LLIF cages was not inferior to that using autologous bone graft. Affinos® is a candidate for graft material in LLIF surgery and further exploration is warranted.

Keywords: Bony fusion; Lateral lumbar interbody fusion (LLIF); β-Tricalcium phosphate artificial bone.

MeSH terms

  • Adult
  • Bone Substitutes / chemistry
  • Bone Substitutes / therapeutic use*
  • Calcium Phosphates / chemistry
  • Calcium Phosphates / therapeutic use*
  • Female
  • Humans
  • Lumbar Vertebrae / surgery
  • Male
  • Middle Aged
  • Porosity
  • Spinal Fusion / methods*

Substances

  • Bone Substitutes
  • Calcium Phosphates
  • beta-tricalcium phosphate