Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization

Org Biomol Chem. 2018 Oct 10;16(39):7109-7114. doi: 10.1039/c8ob02012d.

Abstract

An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydro-quinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free conditions, wide substrate scope, and high step- and atom-economy.

Publication types

  • Research Support, Non-U.S. Gov't