Abstract
We studied microRNA whose expression can be regulated by carcinogenic compounds. Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652). Published data indicate that these microRNAs are oncosuppressors, except miR-31 that can act as an oncogene. The expression of these microRNAs in malignant tumors of the endometrium was studied. The expression of the majority of the studied microRNAs, except miR-652, was 2-3-fold below the normal, which confirms their oncosuppressor function and indicates their involvement in the endometrial carcinogenesis and hence, allows considering them as potential markers of the disease.
Keywords:
AhR; CAR; bioinformatic analysis; endometrial cancer; microRNA.
MeSH terms
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Aged
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Basic Helix-Loop-Helix Transcription Factors / genetics*
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Binding Sites
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Carcinogenesis / genetics*
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Carcinogenesis / metabolism
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Carcinogenesis / pathology
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Computational Biology
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Constitutive Androstane Receptor
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Endometrial Neoplasms / diagnosis
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Endometrial Neoplasms / genetics*
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Endometrial Neoplasms / metabolism
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Endometrial Neoplasms / pathology
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Endometrium / metabolism
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Endometrium / pathology
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic*
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Humans
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MicroRNAs / classification
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MicroRNAs / genetics*
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MicroRNAs / metabolism
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Middle Aged
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Neoplasm Staging
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Receptors, Aryl Hydrocarbon / genetics*
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Receptors, Aryl Hydrocarbon / metabolism
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Receptors, Cytoplasmic and Nuclear / genetics*
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Receptors, Cytoplasmic and Nuclear / metabolism
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Response Elements
Substances
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AHR protein, human
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Basic Helix-Loop-Helix Transcription Factors
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Constitutive Androstane Receptor
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MicroRNAs
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Receptors, Aryl Hydrocarbon
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Receptors, Cytoplasmic and Nuclear