Abstract
We studied the cardioprotective effect of 2,6-diisobornyl-4-methylphenol under conditions of myocardial ischemia/reperfusion in rats. Daily administration of 2,6-diisobornyl-4-methylphenol (100 mg/kg intragastrically) over 3 days before and 5 days after modeling of myocardial ischemia/reperfusion prevented the increase in the infarction area by almost 2 times in comparison with the control by day 5 after recirculation. The type and severity of pathological changes in ECG parameters reflecting necrotic changes in the myocardium under the action of the compound significantly decreased by day 35 of the experiment. Animal survival rate during the first 24 h after ischemia/reperfusion modeling in the experimental group was by 29% higher than in the control group.
Keywords:
2,6-diisobornyl-4-methylphenol; ECG; infarction zone; myocardial ischemia/reperfusion; rats.
MeSH terms
-
Animals
-
Anti-Arrhythmia Agents / chemical synthesis
-
Anti-Arrhythmia Agents / pharmacology*
-
Antioxidants / chemical synthesis
-
Antioxidants / pharmacology*
-
Boron Compounds / chemical synthesis
-
Boron Compounds / pharmacology*
-
Cardiotonic Agents / chemical synthesis
-
Cardiotonic Agents / pharmacology*
-
Coronary Occlusion / drug therapy
-
Coronary Occlusion / mortality
-
Coronary Occlusion / physiopathology
-
Coronary Vessels / surgery
-
Cresols / chemical synthesis
-
Cresols / pharmacology*
-
Drug Administration Schedule
-
Gastric Absorption
-
Heart Rate / drug effects
-
Male
-
Myocardial Infarction / drug therapy*
-
Myocardial Infarction / mortality
-
Myocardial Infarction / physiopathology
-
Myocardial Reperfusion Injury / drug therapy*
-
Myocardial Reperfusion Injury / mortality
-
Myocardial Reperfusion Injury / physiopathology
-
Rats
-
Rats, Wistar
-
Survival Analysis
Substances
-
Anti-Arrhythmia Agents
-
Antioxidants
-
Boron Compounds
-
Cardiotonic Agents
-
Cresols