Advances and Future Perspectives in 4D Bioprinting

Nureddin Ashammakhi; Samad Ahadian; Fan Zengjie; Kasinan Suthiwanich; Farnaz Lorestani; Gorka Orive; Serge Ostrovidov; Ali Khademhosseini

doi:10.1002/biot.201800148

Advances and Future Perspectives in 4D Bioprinting

Biotechnol J. 2018 Dec;13(12):e1800148. doi: 10.1002/biot.201800148. Epub 2018 Nov 15.

Authors

Nureddin Ashammakhi^{1

2

3}, Samad Ahadian^{1

2}, Fan Zengjie^{1

2

4}, Kasinan Suthiwanich^{1

2

5}, Farnaz Lorestani^{1

2

6

7}, Gorka Orive^{8

9

10}, Serge Ostrovidov^{1

2}, Ali Khademhosseini^{1

2

11

12

13

14}

Affiliations

¹ Center for Minimally Invasive Therapeutics (C-MIT), University of California - Los Angeles, Los Angeles, CA 90095, USA.
² Department of Bioengineering, University of California - Los Angeles, Los Angeles, CA 90095, USA.
³ Division of Plastic Surgery, Department of Surgery, Oulu University, Oulu 8000, Finland.
⁴ School of Stomatology, Lanzhou University, Lanzhou 730000, China.
⁵ Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Tokyo 152-8550, Japan.
⁶ Faculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia.
⁷ University Malaya Centre for Ionic Liquids (UMCiL), University of Malaya, Kuala Lumpur 50603, Malaysia.
⁸ Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria 48940, Spain.
⁹ Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Vitoria 28029, Spain.
¹⁰ University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria 48940, Spain.
¹¹ Department of Radiological Sciences, University of California - Los Angeles, Los Angeles, CA 90095, USA.
¹² Department of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA 90095, USA.
¹³ Department of Physics, Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
¹⁴ Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Republic of Korea.

Abstract

Three-dimensionally printed constructs are static and do not recapitulate the dynamic nature of tissues. Four-dimensional (4D) bioprinting has emerged to include conformational changes in printed structures in a predetermined fashion using stimuli-responsive biomaterials and/or cells. The ability to make such dynamic constructs would enable an individual to fabricate tissue structures that can undergo morphological changes. Furthermore, other fields (bioactuation, biorobotics, and biosensing) will benefit from developments in 4D bioprinting. Here, the authors discuss stimuli-responsive biomaterials as potential bioinks for 4D bioprinting. Natural cell forces can also be incorporated into 4D bioprinted structures. The authors introduce mathematical modeling to predict the transition and final state of 4D printed constructs. Different potential applications of 4D bioprinting are also described. Finally, the authors highlight future perspectives for this emerging technology in biomedicine.

Keywords: 4D bioprinting; additive manufacturing; bioinks; stimuli-responsive biomaterials; tissue engineering.

Publication types

Review

MeSH terms

Biocompatible Materials / chemistry
Bioprinting / trends*
Biosensing Techniques
Humans
Models, Theoretical
Printing, Three-Dimensional
Tissue Engineering

Substances

Biocompatible Materials

Abstract

Publication types

MeSH terms

Substances

Grants and funding