[Prognostic value of PD-1/PD-L1 expression in upper tract urothelial carcinoma]

Abstract

Current literature supports the efficacy of anti-PD-1 and anti-PD-L1 immune checkpoint inhibitors for the treatment of urothelial carcinomas. While the prognostic value of PD-1 and PD-L1 levels has been comprehensively analyzed for urothelial carcinoma of the bladder, less is known for upper tract urothelial carcinoma. In addition, available data on the prognostic value of PD-1 and/or PD-L1 level in the tumor and/or peritumoral microenvironment are heterogeneous and even sometimes contradictory. In this article, we compared the methodologies of the various available studies in order to highlight the factors that can explain these discordant results.

Keywords: Carcinome urothélial; Immunohistochemistery; Immunohistochimie; PD-1; PD-L1; Tumeurs de la voie excrétrice urinaire supérieure; Upper tract urothelial carcinoma; Urothelial carcinoma.