RETRACTED: Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression

Biomed Pharmacother. 2018 Dec:108:7-14. doi: 10.1016/j.biopha.2018.09.007. Epub 2018 Sep 10.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concerns were raised about suspected duplicated features between the 'DN' and 'DN+anti-miR-NC' groups within Figure 2I, as detailed here: https://pubpeer.com/publications/FB14889727E5CF2651E012EEA10225#1. A journal investigation confirmed the presence of these suspected duplicated features. The journal asked the authors to provide an explanation to these concerns and the associated raw data. All authors were contacted on several occasions, but the journal did not receive a response. The Editor-in-Chief assessed the case and decided to retract the article.

Keywords: Diabetic nephropathy; High glucose; Streptozotocin; TIMP3; miR-21.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / genetics*
  • Base Sequence
  • Cell Line
  • Diabetic Nephropathies / blood
  • Diabetic Nephropathies / genetics*
  • Diabetic Nephropathies / pathology
  • Down-Regulation / drug effects
  • Down-Regulation / genetics*
  • Female
  • Glucose / toxicity
  • Humans
  • Inflammation / genetics*
  • Kidney / metabolism
  • Kidney / pathology
  • Male
  • Mice
  • MicroRNAs / blood
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Middle Aged
  • Podocytes / drug effects
  • Podocytes / metabolism
  • Podocytes / pathology*
  • Rats, Sprague-Dawley
  • Streptozocin
  • Tissue Inhibitor of Metalloproteinase-3 / genetics*
  • Tissue Inhibitor of Metalloproteinase-3 / metabolism
  • Up-Regulation / genetics

Substances

  • MIRN21 microRNA, human
  • MicroRNAs
  • Tissue Inhibitor of Metalloproteinase-3
  • mirn21 microRNA, rat
  • Streptozocin
  • Glucose