Insights into the respiratory chain and oxidative stress

Véronique Larosa; Claire Remacle

doi:10.1042/BSR20171492

Insights into the respiratory chain and oxidative stress

Biosci Rep. 2018 Oct 2;38(5):BSR20171492. doi: 10.1042/BSR20171492. Print 2018 Oct 31.

Authors

Véronique Larosa¹, Claire Remacle²

Affiliations

¹ Genetics and Physiology of Microalgae, UR InBios/Phytosystems, Chemin de la Vallée, 4, University of Liège, Liège 4000, Belgium.
² Genetics and Physiology of Microalgae, UR InBios/Phytosystems, Chemin de la Vallée, 4, University of Liège, Liège 4000, Belgium c.remacle@ulg.ac.be.

Abstract

Reactive oxygen species (ROS) are highly reactive reduced oxygen molecules that result from aerobic metabolism. The common forms are the superoxide anion (O₂^∙-) and hydrogen peroxide (H₂O₂) and their derived forms, hydroxyl radical (HO∙) and hydroperoxyl radical (HOO∙). Their production sites in mitochondria are reviewed. Even though being highly toxic products, ROS seem important in transducing information from dysfunctional mitochondria. Evidences of signal transduction mediated by ROS in mitochondrial deficiency contexts are then presented in different organisms such as yeast, mammals or photosynthetic organisms.

Keywords: mitochondria; reactive oxygen species; respiratory chain.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Electron Transport / genetics
Hydrogen Peroxide / metabolism*
Mammals / metabolism
Mitochondria / metabolism*
Oxidative Stress*
Photosynthesis / genetics
Plants / metabolism
Reactive Oxygen Species / metabolism
Superoxides / metabolism*
Yeasts / metabolism

Substances

Reactive Oxygen Species
Superoxides
Hydrogen Peroxide