The use of SAMe in chemotherapy-induced liver injury

Crit Rev Oncol Hematol. 2018 Oct:130:70-77. doi: 10.1016/j.critrevonc.2018.06.019. Epub 2018 Jul 31.

Abstract

Drug-induced liver injury (DILI) remains the most common cause of acute liver failure in the Western world. Chemotherapy is one of the major class of drugs most frequently associated with idiosyncratic DILI. For this reason, patients who receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate and which drug doses should be modified. S-adenosylmethionine (SAMe) is an endogenous agent derived from methionine. Its supplementation is effective in the treatment of liver disease, in particular intrahepatic cholestasis (IHC). The target of this review is to analyze the mechanisms of hepatotoxicity of the principal anticancer agents and the role of SAMe in the prevention of this complication.

Keywords: Chemotherapy; Cholestasis; Drug-induced liver injury; Hepatotoxicity; S-adenosylmethionine.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Chemical and Drug Induced Liver Injury / drug therapy*
  • Chemical and Drug Induced Liver Injury / etiology
  • Drug-Related Side Effects and Adverse Reactions / drug therapy*
  • Drug-Related Side Effects and Adverse Reactions / etiology
  • Humans
  • Neoplasms / drug therapy*
  • S-Adenosylmethionine / therapeutic use*

Substances

  • Antineoplastic Agents
  • S-Adenosylmethionine