Noninvasive detection of cancer spread to lymph nodes: A review of molecular imaging principles and protocols

J Surg Oncol. 2018 Aug;118(2):301-314. doi: 10.1002/jso.25124. Epub 2018 Sep 9.

Abstract

Identification of cancer spread to tumor-draining lymph nodes offers critical information for guiding treatment in many cancer types. Current clinical methods of nodal staging are invasive and can have substantial negative side effects. Molecular imaging protocols have long been proposed as a less invasive means of nodal staging, having the potential to enable highly sensitive and specific evaluations. This review article summarizes the current status and future perspectives for molecular targeted nodal staging.

Keywords: lymph node staging; metastasis; molecular imaging; targeted imaging agents.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lymph Nodes / diagnostic imaging*
  • Lymph Nodes / pathology
  • Molecular Imaging / methods*
  • Neoplasm Staging
  • Neoplasms / diagnostic imaging*
  • Neoplasms / pathology
  • Sentinel Lymph Node Biopsy / methods