Obliterating Obstacles to an Odyssey

Massimo Nichane; Kyle M Loh

doi:10.1016/j.stem.2018.08.013

Obliterating Obstacles to an Odyssey

Cell Stem Cell. 2018 Sep 6;23(3):313-315. doi: 10.1016/j.stem.2018.08.013.

Authors

Massimo Nichane¹, Kyle M Loh²

Affiliations

¹ Department of Developmental Biology, Stanford Institute for Stem Cell Biology & Regenerative Medicine, Stanford-UC Berkeley Siebel Stem Cell Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: mnichane@stanford.edu.
² Department of Developmental Biology, Stanford Institute for Stem Cell Biology & Regenerative Medicine, Stanford-UC Berkeley Siebel Stem Cell Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kyleloh@stanford.edu.

PMID: 30193127
DOI: 10.1016/j.stem.2018.08.013

Abstract

Why is reprogramming to generate induced pluripotent stem cells (iPSCs) a protracted and inefficient odyssey? In this issue of Cell Stem Cell, Mor et al. (2018) hypothesize that reprogramming factors paradoxically activate and inhibit pluripotency gene expression and show that eliminating Gatad2a (a NuRD corepressor complex subcomponent) rapidly and efficiently reprograms multiple cell types into iPSCs.

Publication types

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MeSH terms

Gene Expression
Histone Deacetylases
Induced Pluripotent Stem Cells*
Mi-2 Nucleosome Remodeling and Deacetylase Complex*

Substances

Histone Deacetylases
Mi-2 Nucleosome Remodeling and Deacetylase Complex